Uji efektivitas ekstrak etanol daun senggani (Melastoma malabathricum L.) sebagai antihipertensi pada mencit putih jantan (Mus musculus)
نویسندگان
چکیده
Pendahuluan; daun senggani memiliki senyawa metabolit sekunder yang dapat menghambat pengeluaran aldosteron sehingga lebih banyak air dikeluarkan dari tubuh dan tekanan darah akan turun. Tujuan; untuk mengetahui efektivitas ekstrak etanol (Melastoma malabathricum L.) terhadap penurunan mencit putih jantan (Mus musculus). Metode; eksperimental meliputi pengambilan sampel, pengolahan pembuatan ekstrak, karakteristik simplisia, penyiapan bahan uji, perlakuan hewan uji analisa data. Sampel digunakan yaitu malabathircum Hewan adalah 15 ekor kemudian dibagi menjadi 5 kelompok. Pengukuran menggunakan alat blood presure analyzer dengan etode tail cuff. Data hasil pengukuran dianalsis paired t-test batas kemaknaan 0,05. Hasil; antihipertensi sistol paling rendah setelah pada EEDS 150 mg/kgBB 86,66 mmHg diastol diperoleh mg/KgBB 59 mmHg. Hasil statistik adanya pengaruh pemberian 50 mg/kgBB, 100 selama 14 hari p-value < Pada signifikan terdapat = 0,001. Kesimpulan; Pemberian menurunkan coba Ekstrak efektif dalam dosis mg.
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical and Sciences
سال: 2023
ISSN: ['2656-3088']
DOI: https://doi.org/10.36490/journal-jps.com.v6i3.220